When your mind won't stop negotiating with itself.
OCD involves glutamate dysregulation in the cortico-striato-thalamo-cortical (CSTC) circuits — the neural loops responsible for filtering and prioritizing thoughts. When these circuits malfunction, the brain gets stuck in repetitive thought-behavior patterns it cannot break free from on its own.
Unlike SSRIs, which target serotonin and may take 8-12 weeks to show effects for OCD, ketamine works through an entirely different system. It modulates glutamate transmission directly, targeting the CSTC circuits at the root of obsessive-compulsive patterns.
By resetting glutamate signaling in these circuits, ketamine can reduce OCD symptom severity within hours rather than months. This rapid action provides a window of relief that can make therapy more effective and give patients space to build new patterns.
At Music City Ketamine in Franklin, TN, Marla Peterson, CRNA administers every infusion in a private suite with real-time dose adjustment. She understands the unique considerations for OCD patients and creates a calm, controlled environment. Walter or Wilma may stop by to offer some quiet comfort before your session.
Ready to explore whether ketamine therapy is right for you?
Schedule a Consultation"For the first time in years, the intrusive thoughts actually quieted down. They didn't disappear completely, but the volume dropped — like someone finally turned the dial down on the mental noise. I sat in my car after my second infusion and just breathed. I hadn't felt that kind of stillness in so long."
"Marla understood OCD in a way I didn't expect from a ketamine provider. She didn't minimize it or treat me like I was being dramatic. She explained exactly what was happening in my brain and why this might help. Walter sat with me before my session, and honestly, that kind of calm presence made all the difference."
Yes. Research shows ketamine produces statistically significant reductions in OCD severity scores, even in patients who haven't responded to SSRIs or therapy. It works through the glutamate system rather than serotonin, targeting the underlying circuit dysfunction.
Marla Peterson, CRNA is experienced in working with OCD patients. Research suggests starting at a lower dose can help patients become comfortable with the experience. At Music City Ketamine in Franklin, TN, your dose is carefully adjusted in real time.
Clinical studies show effects lasting up to 7 days from a single dose. The standard protocol of 6 infusions over 2-3 weeks, followed by maintenance, aims to produce cumulative and sustained improvement.
If SSRIs and therapy haven't been enough to break the cycle, it might be time to try a different approach. Let's talk about whether ketamine therapy at Music City Ketamine in Franklin, TN is right for you.
Schedule a Conversation Text (615) 988-4600