Ketamine for PTSD

The past doesn't have to keep running the show.

Depression Anxiety PTSD Chronic Pain OCD Addiction Veterans Suicidal Ideation

Is This You?

How Ketamine Helps PTSD

In PTSD, the brain's threat detection system never fully stands down. The amygdala — which processes fear and danger — remains hyperactive, firing alarm signals long after the original threat has passed. Meanwhile, the prefrontal cortex, which should be able to evaluate those signals and say "you're safe now," has been weakened by chronic stress and trauma.

Every time a traumatic memory is recalled, it goes through a process called reconsolidation — it's temporarily destabilized and then re-stored. This is why triggers can feel as vivid and overwhelming as the original event. The memory keeps getting reinforced with its full emotional charge.

Ketamine disrupts fear memory reconsolidation by blocking NMDA receptors during this vulnerable window. This can reduce the emotional intensity of traumatic memories without erasing them — allowing the brain to re-file them as past events rather than present dangers.

Ketamine also reduces amygdala hyperactivity and promotes extinction learning — the process of forming new, safer associations that compete with fear responses. Emerging research shows it can reduce the neuroinflammation associated with chronic trauma, which may contribute to the persistent cognitive and emotional symptoms of PTSD.

At Music City Ketamine in Franklin, TN, Marla Peterson, CRNA administers every infusion in a private suite designed to feel safe and contained. You'll have a weighted blanket, eye mask, and calming music. Walter, our laid-back Director of Hugs, may settle in nearby — a quiet, grounding presence while you rest.

What the Research Shows

67%
treatment response rate for PTSD — vs. 20% placebo
Phase III Randomized Controlled Trial, n=30 — Drugs in Context, 2025
62%
achieved complete PTSD symptom remission with ketamine + psychotherapy
Retrospective Study, n=117 — 2024
1.76
effect size (large) for ketamine in PTSD across military and civilian populations
Frontiers in Psychiatry — Meta-Analysis, 2024

Ready to explore whether ketamine therapy is right for you?

Schedule a Consultation
Or call (615) 988-4600 · Music City Ketamine, Franklin, TN

What Our Patients Say

★★★★★
"For years, the memories were right there — always on the surface, always ready to pull me under. After my fourth infusion, I noticed something different. The memories were still there, but there was space between me and them. I could think about what happened without being back in it. I didn't know that was possible."
— Patient, treated for PTSD
★★★★★
"I almost didn't go through with it. But Marla made me feel safe from the very first conversation. She explained everything, checked in constantly, and never rushed me. Having the dogs there — Walter just lying quietly nearby — made it feel less clinical and more like somewhere I could actually let my guard down."
— Patient, treated for PTSD

Frequently Asked Questions

How does ketamine treatment differ from exposure therapy for PTSD?

Different mechanism. While exposure therapy works by repeatedly facing triggers in a safe environment, ketamine works on the neurobiological level by disrupting fear memory reconsolidation and promoting new neural pathways. Many patients find ketamine can complement their existing therapy.

Is ketamine safe for complex PTSD?

Marla Peterson, CRNA has 20+ years of anesthesia experience and monitors every infusion in real time at Music City Ketamine in Franklin, TN. The dose is carefully controlled to stay within the therapeutic range. Many patients with complex trauma find the experience calming rather than triggering.

How many treatments will I need for PTSD?

The standard protocol is 6 infusions over 2-3 weeks. Research shows that repeated infusions produce more sustained improvement than single doses. Maintenance sessions are tailored to your individual response. At Music City Ketamine, Marla Peterson, CRNA creates a personalized treatment plan for each patient.

You Don't Have to Keep Living in Survival Mode

If your nervous system is still stuck in the past, ketamine therapy may offer a way to process what happened and move forward. Let's talk about whether treatment at Music City Ketamine in Franklin, TN is right for you.

Schedule a Conversation Text (615) 988-4600
Or call (615) 988-4600 · Flexible hours including evenings and weekends